Associate Professor,
Dept. of Molecular and Medical Genetics
Coordinator, Collaborative Graduate Program in Developmental Biology
University of Toronto
office telephone: 416-978-6406
lab telephone: 416-946-3372
e-mail: andrew.spence@utoronto.ca
To Spence lab pages.
Curriculum Vitae
Education
Post-doctoral research
Academic Appointments
Administrative Duties
Teaching
Current Research Funding
Publications
Grant reviewing, reviewing for journals
| B.Sc.(Hons.) | 1980. | University of Winnipeg |
| Field: | Biology and Chemistry | |
| Ph.D. | 1986 | University of British Columbia |
| Field: | Molecular Biology | |
| Thesis Supervisor: | Dr. Michael Smith | |
| Thesis Title: | Mutational Analysis of the Transcript 3' End Signal of the CYC1 Gene of Yeast |
Post-doctoral research experience
| 1985-86 | Dept. of Physiology, University of Manitoba |
| 1986-1989 | MRC Laboratory of Molecular Biology, Cambridge, UK Research supervisor: Dr. Jonathan Hodgkin |
| 1990 | Visiting scientist, Centre de Recherches de Biologie Macromoléculaire du CNRS, Montpellier, France |
| 1984-85 | Sessional lecturer | Dept. of Microbiology, University of Manitoba |
| 1991-96 | Assistant Professor | Dept. of Molecular and Medical Genetics, University of Toronto |
| 1996-present | Associate Professor | Dept. of Molecular and Medical Genetics, University of Toronto |
| 1998-present | Program Coordinator | Collaborative Program in Developmental Biology, University of Toronto |
| 2001-present | Member | Department Credentials Committee |
1993-1999: MGB450S Genetics of Selected Eukaryotes
instructor: 7-8 hours of lectures
1999-2002: MGB451F Genetic Analysis of Development
instructor, coordinator: 12 hours of lectures
course outline
Developmental Genetics of C. elegans: lecture notes
1996-2002: JDB1025Y Developmental Biology
1997-2001, instructor; 1998-2001, coordinator: 38 hours class discussion
1996, 2002: guest discussant, 2 hours
course outline
1997-2002: MMG1016Y Advanced Genetics
instructor: 12 hours class discussion
Graduate student supervision
currently supervising 4 graduate students: 3 Ph.D., 1 M.Sc. - see lab pages
currently a member of 12 other student supervisory committees
| Canadian Institutes of Health Research | Signal transduction in C. elegans sex determination | 1999-2002 | |
| Protein Engineering Network of Centres of Excellence (with Dr. Harry Schachter) | The role of N-glycans in the development of Caenorhabditis elegans | 2001-2005 | |
| Genome Canada | Functional genomics and proteomics of C. elegans | 2002-2005 | |
| Canadian Institutes of Health Research | Genetic regulation of gonadogenesis in C. elegans | 2002-2005 |
Schachter, H., S. Chen, and A.M. Spence. 2001. Complex N-glycans: when, why? Trends in Glycoscience and Glycotechnology. submitted.
Gaudet, J., J. Schein, M. Marra, T. Kucaba, and A.M. Spence. 2001. Functional divergence of the fem-1 sex-determining gene in Caenorhabditis. Genetics, in revision.
Lum, D.H., P. Kuwabara, D. Zarkower, and A.M. Spence. 2000. Direct interaction between the intracellular domain of the feminising receptor TRA-2A and the transcription factor TRA-1A. Genes & Development, 14: 3153-3165.
Pilon, M. X.-R. Peng, A.M. Spence, R.H.A. Plasterk, and H.M. Dosch. 2000. The diabetes autoantigen ICA69 and its C. elegans homolog, ric-19, are conserved regulators of neuroendocrine secretion. Mol. Biol. Cell, 11: 3277-3288.
Mehra, A., J. Gaudet, L. Heck, P.E. Kuwabara, and A.M. Spence. 1999. Negative regulation of male development in Caenorhabditis elegans by a protein-protein interaction between TRA-2A and FEM-3. Genes & Development 13: 1453-1463.
Chen, S., S. Zhou, M. Sarkar, A.M. Spence, and H. Schachter. 1999. Expression of three Caenorhabditis elegans N-Acetylglucosaminyltransferase I genes during development. J. Biol. Chem. 274: 288-297.
Rossant, J. and A. Spence. 1998. Chimeras and mosaics in mouse mutant analysis. Trends in Genetics 14: 358-363.
Chin-Sang, I.D., and A.M. Spence. 1996. C. elegans Sex-Determining Protein FEM-2 is a Masculinizing Protein Phosphatase that Interacts Directly with FEM-3. Genes & Development 10: 2314-2325.
Gaudet, J., I. VanderElst, and A.M. Spence. 1996. Post-transcriptional regulation of sex determination in Caenorhabditis elegans: Widespread expression of the sex-determining gene fem-1 in both sexes. Mol. Biol. Cell 7: 1107-1121.
Leung-Hagesteijn, C., A.M. Spence, B.D. Stern, Y. Zhou, M.W. Su, E.M. Hedgecock, J.G. Culotti. 1992. UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type I domains, guides cell and pioneer axon migrations in C. elegans. Cell 71: 289-299.
Spence, A.M., A. Coulson, and J. Hodgkin. 1990. The product of fem-1, a nematode sex-determining gene, contains a motif found in cell-cycle control proteins and receptors for cell-cell interactions. Cell 60: 981-990.
| 2000-present | Member | CIHR (formerly MRC) grant review committee - Genetics |
| 1997,1999,2000 | Invitee | MRC grant review committee - Genetics |
| 1992-present | ad hoc reviewer | MRC, NSERC, Heart and Stroke Foundation, FCAR |
Reviewing for Journals
Cell/Molecular Cell, Development, Developmental Biology, EMBO Journal,
Genes & Development, Genetics, Genome, Molecular Biology of the Cell, Science
To Spence lab pages.
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