MGB 451F Genetic analysis of development: yeast and worms

Section 2: Genetic analysis of Caenorhabditis elegans

• Lectures 1,2.
  Introduction to C. elegans and its use in the genetic analysis of development:

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  • life cycle
  • useful features - genetics, cell lineage, genome sequence
  • basic genetic analysis: mutagenesis, simple mutant screens, mapping, complementation testing
  • making inferences about gene function: gain- and loss-of-function mutations
  • why do null alleles matter and how do you know whether you've got one?
  • gene dosage tests
  • non-complementation screens
  • reversion of dominant alleles

    Basic genetics practice:

    • Problem set
    • Solutions
  • Take home test: Genetics problems
  • Solutions to take home test.
• Lecture 3
  Genetic analysis of programmed cell death

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• Lecture 4
  Early Embryogenesis in C. elegans

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Lecture 5
Genetic Mosaic Analysis

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Final Exam

Tuesday, December 16, 2003
9:00-12:00 A.M.
Room 110, Ramsay Wright Zoological Laboratories
25 Harbord Ave.

Exam is worth 50% of Final Grade.

Practice: 2002 Final Exam.

This page last updated December 14, 2003